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76 Adverse Reactions and Drug Interactions Theophylline is associated with a wide range of adverse effects, including central nervous system excitation (manifested as restlessness, tremors, and seizures), 72 gastrointestinal upset (nausea and vomiting), diuresis, and cardiac stimulation (e.g., tachycardia)

Increase if needed within the safe range

Efficacy and safety of initial combination therapy with gemigliptin and metformin compared with monotherapy with either drug in patients with type 2 diabetes: A double-blind randomized controlled trial (INICOM study)